SQLE

Across TCGA cell cohorts, SQLE RNA expression is significantly associated with the go_rna of many other GO terms, with 2,816 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SQLE-associated GO terms across cancer lineages are Cholesterol biosynthetic process, Isopentenyl diphosphate biosynthetic process, and Farnesyl diphosphate biosynthetic process, mevalonate pathway. Each is linked with SQLE in more than 19 cancer types. Because this analysis shows association rather than direction, both SQLE-to-partner and partner-to-SQLE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cholesterol biosynthetic process grouped by SQLE-low versus SQLE-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SQLE→partner) and Y-score (partner→SQLE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Cholesterol biosynthetic process →	+0.227	+1.813	<.001	<.001	3	20
STOMACH	Isopentenyl diphosphate biosynthetic process →	+0.190	+1.893	<.001	<.001	3	20
STOMACH	Farnesyl diphosphate biosynthetic process, mevalonate pathway →	+0.211	+1.959	<.001	<.001	3	20
BONE	Sterol biosynthetic process →	+0.215	+1.248	<.001	<.001	3	20
OESOPHAGUS	Secondary alcohol biosynthetic process →	+0.227	+1.813	<.001	<.001	3	20
STOMACH	Isoprenoid biosynthetic process via mevalonate →	+0.211	+1.959	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,816 associations by consensus.

Cholesterol biosynthetic process by SQLE expression — OESOPHAGUS

Explore this box plot interactively →