SQLE

Across TCGA cell cohorts, SQLE mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible SQLE-associated genes across cancer lineages are RETNLB, SPATA31D3, and CROCC2. Each is linked with SQLE in more than 1 cancer types. Because this analysis shows association rather than direction, both SQLE-to-partner and partner-to-SQLE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RETNLB grouped by SQLE-low versus SQLE-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SQLE→partner) and Y-score (partner→SQLE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RETNLB →	+0.142	+4.237	<.001	.006	3	1
PANCREAS	SPATA31D3 →	+0.005	+4.614	<.001	.004	3	1
PANCREAS	CROCC2 →	+0.085	+4.237	<.001	.006	3	1
PANCREAS	GDF10 →	+0.276	+4.786	<.001	.001	3	1
OVARY	VCY1B →	+0.291	+4.029	<.001	.009	3	1
OVARY	GAGE12D →	+0.330	+4.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

RETNLB by SQLE expression — PANCREAS

Explore this box plot interactively →