SQLE

Across TCGA cell cohorts, SQLE mutation is significantly associated with the mutation status of many other genes, with 2,453 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SQLE-associated genes across cancer lineages are PRPF40A, RBL1, and SH3TC1. Each is linked with SQLE in more than 2 cancer types. Because this analysis shows association rather than direction, both SQLE-to-partner and partner-to-SQLE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRPF40A grouped by SQLE-low versus SQLE-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SQLE→partner) and Y-score (partner→SQLE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PRPF40A →	+5.297	+5.297	.004	.004	1	3
BLOOD_Leukemia	RBL1 →	+4.321	+5.285	.005	.005	1	3
LARGE_INTESTINE	SH3TC1 →	+2.152	+2.787	.005	.005	1	3
LARGE_INTESTINE	LAMB3 →	+2.263	+3.392	.001	.001	1	3
BREAST	CCAR1 →	+4.297	+4.857	.009	.009	1	2
BREAST	ATG2B →	+4.297	+4.857	.009	.009	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,453 associations by consensus.

PRPF40A by SQLE expression — BREAST

Explore this box plot interactively →