SPZ1

Across TCGA patient cohorts, SPZ1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,607 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SPZ1-associated GO terms across cancer lineages are Regulation of double-strand break repair via homologous recombination, mRNA 3'-end processing, and Negative regulation of DNA-templated transcription, elongation. Each is linked with SPZ1 in more than 15 cancer types. Because this analysis shows association rather than direction, both SPZ1-to-partner and partner-to-SPZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of double-strand break repair via homologous recombination grouped by SPZ1-low versus SPZ1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPZ1→partner) and Y-score (partner→SPZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of double-strand break repair via homologous recombination →	+0.047	+0.084	<.001	<.001	3	15
STAD	mRNA 3'-end processing →	+0.052	+0.078	<.001	<.001	3	15
STAD	Negative regulation of DNA-templated transcription, elongation →	+0.050	+0.071	<.001	<.001	3	15
STAD	Positive regulation of DNA repair →	+0.048	+0.090	<.001	<.001	3	15
STAD	Cell cycle checkpoint signaling →	+0.050	+0.077	<.001	<.001	3	14
STAD	Sister chromatid segregation →	+0.056	+0.088	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,607 associations by consensus.

Regulation of double-strand break repair via homologous recombination by SPZ1 expression — STAD

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