SPZ1

Across TCGA pan-cancer cohorts, SPZ1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated SPZ1 data layer compared with 5 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher SPZ1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SPZ1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and MESO show a favorable association.

KICH, BLCA, and ACC are the cancer types where SPZ1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Tertile	All	0.769	0.977	<.001	96	view →
BLCA	DFS	Tertile	All	0.533	0.656	.007	44	view →
ACC	DFS	Tertile	III,IV	0.046	0.670	.001	36	view →
UVM	DFS	Tertile	All	0.221	0.772	.010	36	view →
COAD	DFS	Tertile	II,III,IV	0.225	0.497	.001	34	view →
LUAD	DFS	Quartile	All	0.592	0.273	.004	30	view →
MESO	OS	Tertile	All	0.942	0.516	.017	27	view →
SCLC	DFS	Tertile	II,III,IV	0.225	0.504	.020	18	view →
READ	DFS	Tertile	II,III,IV	0.822	0.241	.013	17	view →
ESCA	DFS	Tertile	III,IV	0.530	0.222	.025	16	view →
LGG	DFS	Tertile	All	0.576	0.773	.037	9	view →
THYM	DFS	Tertile	All	0.643	0.912	.015	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

SPZ1–KICH (OS)

Open the KICH breakdown →