SPZ1

Across TCGA patient cohorts, SPZ1 mutation is significantly associated with the RNA expression of many other genes, with 2,974 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPZ1-associated genes across cancer lineages are RN7SKP221, AATF, and PELO. Each is linked with SPZ1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPZ1-to-partner and partner-to-SPZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP221 grouped by SPZ1-low versus SPZ1-high in KIRC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPZ1→partner) and Y-score (partner→SPZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	RN7SKP221 →	+0.104	+8.025	<.001	.007	3	3
UCEC	AATF →	+0.479	+4.160	<.001	<.001	3	2
UCEC	PELO →	+0.461	+4.043	<.001	<.001	3	2
UCEC	CWC27 →	+0.441	+2.287	.002	.005	3	2
UCEC	BUB3 →	+0.516	+2.075	<.001	.004	3	2
UCEC	TATDN2 →	+0.345	+2.665	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,974 associations by consensus.

RN7SKP221 by SPZ1 expression — KIRC

Explore this box plot interactively →