SPZ1

Across TCGA cell cohorts, SPZ1 RNA expression is significantly associated with the go_rna of many other GO terms, with 196 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPZ1-associated GO terms across cancer lineages are Detection of lipopolysaccharide, Regulation of T cell migration, and Regulation of response to tumor cell. Each is linked with SPZ1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPZ1-to-partner and partner-to-SPZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Detection of lipopolysaccharide grouped by SPZ1-low versus SPZ1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPZ1→partner) and Y-score (partner→SPZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Detection of lipopolysaccharide →	+0.220	+0.040	<.001	.007	3	3
BLOOD_Myeloma	Regulation of T cell migration →	+0.067	+0.059	.008	.003	3	2
LARGE_INTESTINE	Regulation of response to tumor cell →	+0.085	+0.032	<.001	.005	3	2
LARGE_INTESTINE	Liposaccharide metabolic process →	+0.029	+0.028	.006	.002	3	2
LARGE_INTESTINE	Regulation of immune response to tumor cell →	+0.098	+0.034	<.001	<.001	3	2
LARGE_INTESTINE	Positive regulation of mitochondrial membrane permeability →	-0.043	-0.033	.007	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 196 associations by consensus.

Detection of lipopolysaccharide by SPZ1 expression — BLOOD_Myeloma

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