SPZ1

Across TCGA cell cohorts, SPZ1 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SPZ1-associated genes across cancer lineages are OBP2A, C5orf52, and OBP2B. Each is linked with SPZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPZ1-to-partner and partner-to-SPZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OBP2A grouped by SPZ1-low versus SPZ1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPZ1→partner) and Y-score (partner→SPZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OBP2A →	+0.553	+5.369	<.001	.004	3	2
SOFT_TISSUE	C5orf52 →	+0.033	+5.977	<.001	.001	3	2
SOFT_TISSUE	OBP2B →	+0.134	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR4X2 →	+0.032	+5.369	<.001	.004	3	1
SOFT_TISSUE	C12orf40 →	+0.383	+4.930	<.001	.008	3	1
SOFT_TISSUE	PRR20B →	+0.043	+5.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

OBP2A by SPZ1 expression — SOFT_TISSUE

Explore this box plot interactively →