SPX

Across TCGA pan-cancer cohorts, SPX Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SPX data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher SPX Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPX expression acts as an unfavorable survival marker.

SKCM, READ, and KIRP are the cancer types where SPX Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	III,IV	0.072	0.814	<.001	28	view →
READ	OS	Median	III,IV	0.328	0.751	.003	12	view →
KIRP	OS	Median	All	0.608	0.903	.021	9	view →
STAD	OS	Median	II,III,IV	0.228	0.571	.035	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SPX–SKCM (OS)

Open the SKCM breakdown →