SPX

Across TCGA pan-cancer cohorts, SPX RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of SPX’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SPX RNA is repressed in tumor relative to normal tissue. In most cancer types SPX is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and BLCA are the cancer types where SPX tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPX RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−4.904	<.001	11	view →
KIRC	Male	All	−1.173	<.001	9	view →
BLCA	Male	IV	−0.375	<.001	9	view →
HNSC	Male	All	−1.153	<.001	8	view →
COAD	All	II,III,IV	−0.201	<.001	8	view →
LUAD	Female	III,IV	−1.332	<.001	7	view →
STAD	All	All	−0.793	<.001	7	view →
BRCA	All	III,IV	−3.165	<.001	6	view →
KIRP	Male	II,III,IV	+1.787	<.001	6	view →
LUSC	Female	II,III,IV	−1.501	<.001	6	view →
UCEC	All	All	+1.363	<.001	6	view →
CHOL	Female	All	−1.643	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

SPX–THCA

Open the THCA breakdown →