SPX

Across TCGA pan-cancer cohorts, SPX mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SPX data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SPX mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SPX expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, CCRCC, and UCEC are the cancer types where SPX mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.691	0.147	<.001	26	view →
CCRCC	DFS	Tertile	III,IV	0.231	0.715	.014	9	view →
UCEC	OS	Quartile	All	1.000	0.685	.022	8	view →
HNSC	DFS	Median	IV	0.942	0.622	.033	3	view →
LUAD	DFS	Median	All	0.960	0.890	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SPX–PDAC (DFS)

Open the PDAC breakdown →