SPX

Across TCGA patient cohorts, SPX RNA expression is significantly associated with the protein abundance of many other proteins, with 14,126 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SPX-associated proteins across cancer lineages are RPS19, TLN2, and PTBP2. Each is linked with SPX in more than 3 cancer types. Because this analysis shows association rather than direction, both SPX-to-partner and partner-to-SPX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPX versus RPS19 in PDAC, with a Pearson correlation of -0.30.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPX→partner) and Y-score (partner→SPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RPS19 →	-0.269	-0.341	<.001	.005	3	4
HNSC	TLN2 →	+0.391	+0.329	<.001	.007	3	4
LSCC	PTBP2 →	+0.620	+0.342	<.001	.002	3	4
PDAC	SDAD1_S585 →	-0.715	-0.604	<.001	<.001	3	3
HNSC	SETMAR →	+0.336	+0.321	<.001	.002	3	3
GBM	ATRX_S1996 →	-0.469	-0.802	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,126 associations by consensus.

SPX vs RPS19 — PDAC

Explore this scatter interactively →