SPX

Across TCGA patient cohorts, SPX protein abundance is significantly associated with the RNA expression of many other genes, with 2,827 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SPX-associated genes across cancer lineages are SAFB, THOP1, and TNC. Each is linked with SPX in more than 2 cancer types. Because this analysis shows association rather than direction, both SPX-to-partner and partner-to-SPX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPX versus SAFB in LSCC, with a Pearson correlation of -0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPX→partner) and Y-score (partner→SPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SAFB →	-0.438	-0.664	.003	.004	3	3
LSCC	THOP1 →	-0.556	-0.748	.004	<.001	3	3
PDAC	TNC →	-2.364	-1.057	.002	.001	3	3
UCEC	DNMT1 →	-0.636	-0.865	.002	.001	3	2
UCEC	TRAF7 →	-0.897	-0.643	.002	.005	3	2
UCEC	AGAP3 →	-0.496	-0.609	.009	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,827 associations by consensus.

SPX vs SAFB — LSCC

Explore this scatter interactively →