SPX

Across TCGA patient cohorts, SPX mutation is significantly associated with the RNA expression of many other genes, with 318 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SPX-associated genes across cancer lineages are OR6U2P, SNX3P1Y, and IFNA16. Each is linked with SPX in more than 2 cancer types. Because this analysis shows association rather than direction, both SPX-to-partner and partner-to-SPX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6U2P grouped by SPX-low versus SPX-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPX→partner) and Y-score (partner→SPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	OR6U2P →	+0.194	+4.440	<.001	.006	3	3
UCEC	SNX3P1Y →	+0.162	+5.308	<.001	.001	3	2
STAD	IFNA16 →	+0.106	+5.465	<.001	<.001	3	2
STAD	OR5M3 →	+0.093	+5.396	<.001	<.001	3	2
STAD	OR4L1 →	+0.243	+4.646	<.001	.004	3	2
STAD	FAM27E5 →	+0.326	+4.401	.004	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 318 associations by consensus.

OR6U2P by SPX expression — STAD

Explore this box plot interactively →