SPX

Across TCGA patient cohorts, SPX mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPX-associated genes across cancer lineages are Ku80 and BRD4. Each is linked with SPX in more than 1 cancer types. Because this analysis shows association rather than direction, both SPX-to-partner and partner-to-SPX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by SPX-low versus SPX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPX→partner) and Y-score (partner→SPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.304	+2.820	.035	.036	3	1
UCEC	BRD4 →	+0.471	+2.818	.004	.035	2	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Ku80 by SPX expression — UCEC

Explore this box plot interactively →