SPX

Across TCGA cell cohorts, SPX RNA expression is significantly associated with the go_rna of many other GO terms, with 2,697 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SPX-associated GO terms across cancer lineages are Cytoplasmic translation, Establishment of protein localization to organelle, and Golgi vesicle transport. Each is linked with SPX in more than 9 cancer types. Because this analysis shows association rather than direction, both SPX-to-partner and partner-to-SPX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasmic translation grouped by SPX-low versus SPX-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPX→partner) and Y-score (partner→SPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Cytoplasmic translation →	+0.095	+0.686	<.001	.003	3	10
OESOPHAGUS	Establishment of protein localization to organelle →	+0.050	+0.636	.001	.006	3	10
SOFT_TISSUE	Golgi vesicle transport →	+0.050	+1.541	.001	.001	3	9
OVARY	Potassium ion transport →	-0.073	-1.339	<.001	.003	3	9
UPPER_AERODIGESTIVE_TRACT	Potassium ion transmembrane transport →	-0.074	-0.419	<.001	.002	3	9
SOFT_TISSUE	Axoneme assembly →	-0.047	-0.870	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,697 associations by consensus.

Cytoplasmic translation by SPX expression — OESOPHAGUS

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