SPTLC3

Across TCGA patient cohorts, SPTLC3 mutation is significantly associated with the RNA expression of many other genes, with 5,896 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPTLC3-associated genes across cancer lineages are RNA5SP411, NCOA4P1, and MRPS18BP2. Each is linked with SPTLC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPTLC3-to-partner and partner-to-SPTLC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP411 grouped by SPTLC3-low versus SPTLC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTLC3→partner) and Y-score (partner→SPTLC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+0.723	+1.393	<.001	.007	3	3
UCEC	NCOA4P1 →	+0.050	+1.416	<.001	.005	3	3
LUAD	MRPS18BP2 →	+0.067	+4.554	<.001	.009	3	3
UCEC	GXYLT1 →	+0.404	+1.617	.002	.001	3	3
UCEC	NCAPD3 →	+0.732	+1.818	<.001	<.001	3	3
UCEC	BUB1B →	+0.693	+1.818	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,896 associations by consensus.

RNA5SP411 by SPTLC3 expression — UCEC

Explore this box plot interactively →