SPTLC2

Across TCGA patient cohorts, SPTLC2 mutation is significantly associated with the RNA expression of many other genes, with 5,929 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPTLC2-associated genes across cancer lineages are MIR548Q, ATP6V1E1P2, and SNX3P1Y. Each is linked with SPTLC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPTLC2-to-partner and partner-to-SPTLC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548Q grouped by SPTLC2-low versus SPTLC2-high in KIRP.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTLC2→partner) and Y-score (partner→SPTLC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	MIR548Q →	+0.499	+6.103	<.001	.002	3	2
UCEC	ATP6V1E1P2 →	+0.144	+1.829	<.001	.004	3	2
UCEC	SNX3P1Y →	+0.065	+3.834	<.001	.007	3	2
BRCA	KRTAP19-3 →	+0.083	+5.971	.001	.002	3	2
COAD	RNU6-1064P →	+0.451	+3.321	<.001	.008	3	2
COAD	SS18L2P2 →	+0.146	+4.595	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,929 associations by consensus.

MIR548Q by SPTLC2 expression — KIRP

Explore this box plot interactively →