SPTLC2

Across TCGA patient cohorts, SPTLC2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPTLC2-associated genes across cancer lineages are eIF4E, INPP4B, and STAT5a. Each is linked with SPTLC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPTLC2-to-partner and partner-to-SPTLC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SPTLC2-low versus SPTLC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTLC2→partner) and Y-score (partner→SPTLC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.221	+3.247	.006	<.001	3	2
UCEC	INPP4B →	-0.313	-2.906	.011	.001	3	2
UCEC	STAT5a →	+0.323	+2.584	.035	.010	3	2
UCEC	ASNS →	+0.667	+3.000	<.001	<.001	3	2
UCEC	Cyclin-E2 →	+0.175	+2.087	.006	.005	3	2
UCEC	14-3-3_beta →	-0.089	-1.847	.020	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

eIF4E by SPTLC2 expression — UCEC

Explore this box plot interactively →