SPTLC2

Across TCGA cell cohorts, SPTLC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,279 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SPTLC2-associated GO terms across cancer lineages are Regulation of lipophagy, Positive regulation of lipophagy, and Sphingomyelin biosynthetic process. Each is linked with SPTLC2 in more than 17 cancer types. Because this analysis shows association rather than direction, both SPTLC2-to-partner and partner-to-SPTLC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of lipophagy grouped by SPTLC2-low versus SPTLC2-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTLC2→partner) and Y-score (partner→SPTLC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of lipophagy →	+0.189	+1.109	<.001	<.001	2	18
KIDNEY	Positive regulation of lipophagy →	+0.189	+1.109	<.001	<.001	2	18
LUNG_SCLC	Sphingomyelin biosynthetic process →	+0.133	+1.101	<.001	<.001	3	13
SOFT_TISSUE	ERBB3 signaling pathway →	+0.187	+0.900	<.001	<.001	3	13
SOFT_TISSUE	ERBB2-ERBB3 signaling pathway →	+0.187	+0.900	<.001	<.001	3	13
PANCREAS	Protein localization to plasma membrane →	+0.062	+0.811	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,279 associations by consensus.

Regulation of lipophagy by SPTLC2 expression — KIDNEY

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