SPTLC2

Across TCGA cell cohorts, SPTLC2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPTLC2-associated genes across cancer lineages are ACSM6, SMIM23, and IQCF5. Each is linked with SPTLC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPTLC2-to-partner and partner-to-SPTLC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACSM6 grouped by SPTLC2-low versus SPTLC2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTLC2→partner) and Y-score (partner→SPTLC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACSM6 →	+0.019	+3.000	.001	.005	3	1
BLOOD_Leukemia	SMIM23 →	+0.030	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	IQCF5 →	+0.121	+5.201	<.001	.006	3	1
LARGE_INTESTINE	C9orf153 →	+0.232	+3.497	<.001	.004	2	1
LARGE_INTESTINE	TBR1 →	+0.037	+3.555	.001	.003	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ACSM6 by SPTLC2 expression — LARGE_INTESTINE

Explore this box plot interactively →