SPTLC1P4

Across TCGA patient cohorts, SPTLC1P4 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,417 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SPTLC1P4-associated GO terms across cancer lineages are Regulation of proteasomal ubiquitin-dependent protein catabolic process, Positive regulation of proteasomal ubiquitin-dependent protein catabolic process, and Golgi disassembly. Each is linked with SPTLC1P4 in more than 8 cancer types. Because this analysis shows association rather than direction, both SPTLC1P4-to-partner and partner-to-SPTLC1P4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of proteasomal ubiquitin-dependent protein catabolic process grouped by SPTLC1P4-low versus SPTLC1P4-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTLC1P4→partner) and Y-score (partner→SPTLC1P4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.044	+0.125	<.001	<.001	3	9
STAD	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.045	+0.144	<.001	<.001	3	9
STAD	Golgi disassembly →	+0.036	+0.127	<.001	<.001	3	8
STAD	Positive regulation of telomere maintenance →	+0.047	+0.126	<.001	<.001	3	8
STAD	Cellular response to unfolded protein →	+0.070	+0.195	<.001	<.001	3	8
STAD	Sphingomyelin biosynthetic process →	+0.056	+0.156	<.001	.001	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,417 associations by consensus.

Regulation of proteasomal ubiquitin-dependent protein catabolic process by SPTLC1P4 expression — STAD

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