SPTLC1P4

Across TCGA pan-cancer cohorts, SPTLC1P4 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated SPTLC1P4 data layer.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher SPTLC1P4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SPTLC1P4 expression acts as an unfavorable survival marker, although some lineages such as CHOL and ESCA show a favorable association.

DLBC, KIRC, and UCS are the cancer types where SPTLC1P4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Tertile	All	0.136	0.855	<.001	133	view →
KIRC	DFS	Quartile	III,IV	0.272	0.540	<.001	106	view →
UCS	OS	Tertile	All	0.342	0.686	.001	84	view →
CHOL	DFS	Median	II,III,IV	0.633	0.098	<.001	44	view →
BLCA	DFS	Quartile	All	0.400	0.566	.001	42	view →
ESCA	DFS	Tertile	IV	0.704	0.213	.017	30	view →
STAD	DFS	Quartile	All	0.357	0.629	.001	30	view →
COAD	OS	Median	All	0.855	0.768	.016	25	view →
SKCM	DFS	Tertile	IV	0.052	0.528	<.001	24	view →
BRCA	OS	Tertile	III,IV	0.841	0.929	.006	16	view →
LGG	OS	Tertile	All	0.787	0.932	<.001	12	view →
KIRP	OS	Quartile	All	0.468	0.727	.004	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

SPTLC1P4–DLBC (OS)

Open the DLBC breakdown →