SPTLC1

Across TCGA patient cohorts, SPTLC1 mutation is significantly associated with the RNA expression of many other genes, with 499 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPTLC1-associated genes across cancer lineages are USP9YP10, OR8B8, and MTND4LP22. Each is linked with SPTLC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPTLC1-to-partner and partner-to-SPTLC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP9YP10 grouped by SPTLC1-low versus SPTLC1-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTLC1→partner) and Y-score (partner→SPTLC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	2
BLCA	OR8B8 →	+0.050	+5.899	<.001	.002	3	2
CESC	MTND4LP22 →	+0.115	+6.837	<.001	<.001	3	2
CESC	MIR4652 →	+0.362	+5.103	.001	.008	3	2
HNSC	SNORD114-1 →	+0.659	+5.124	<.001	.008	3	2
LUAD	RNA5SP391 →	+0.248	+7.930	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 499 associations by consensus.

USP9YP10 by SPTLC1 expression — LGG

Explore this box plot interactively →