SPTBN2

Across TCGA patient cohorts, SPTBN2 mutation is significantly associated with the RNA expression of many other genes, with 5,697 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPTBN2-associated genes across cancer lineages are CKS2, F10, and RGN. Each is linked with SPTBN2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPTBN2-to-partner and partner-to-SPTBN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CKS2 grouped by SPTBN2-low versus SPTBN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTBN2→partner) and Y-score (partner→SPTBN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CKS2 →	+0.384	+1.712	.001	<.001	3	4
UCEC	F10 →	-0.445	-1.706	.002	<.001	3	4
UCEC	RGN →	-0.453	-1.978	<.001	<.001	3	4
UCEC	CFAP300 →	-0.657	-1.082	.001	.002	3	4
UCEC	PLRG1 →	+0.394	+1.436	<.001	<.001	3	4
COAD	CLEC3B →	-0.754	-2.959	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,697 associations by consensus.

CKS2 by SPTBN2 expression — UCEC

Explore this box plot interactively →