SPTBN2

Across TCGA cell cohorts, SPTBN2 mutation is significantly associated with the RNA expression of many other genes, with 2,733 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPTBN2-associated genes across cancer lineages are FEM1A, C9orf72, and HDAC3. Each is linked with SPTBN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPTBN2-to-partner and partner-to-SPTBN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FEM1A grouped by SPTBN2-low versus SPTBN2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTBN2→partner) and Y-score (partner→SPTBN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FEM1A →	+0.688	+3.614	<.001	<.001	3	3
LARGE_INTESTINE	C9orf72 →	+0.812	+4.043	<.001	<.001	3	3
LARGE_INTESTINE	HDAC3 →	+0.369	+2.949	.004	<.001	3	3
LARGE_INTESTINE	MARCHF5 →	+0.784	+3.584	<.001	<.001	3	3
BLOOD_Leukemia	CACNB1 →	+1.085	+3.614	.004	<.001	3	3
BLOOD_Leukemia	FAM76A →	+0.562	+2.489	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,733 associations by consensus.

FEM1A by SPTBN2 expression — BLOOD_Leukemia

Explore this box plot interactively →