SPTA1

Across TCGA pan-cancer cohorts, SPTA1 Mutation is linked to patient survival in 13 of 34 cancer types, making it a survival-associated SPTA1 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SPTA1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPTA1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and SKCM show a favorable association.

ACC, CESC, and LUSC are the cancer types where SPTA1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.052	0.683	<.001	29	view →
CESC	DFS	Median	III,IV	0.199	0.737	.001	24	view →
LUSC	OS	Median	III,IV	0.978	0.599	.008	22	view →
LIHC	OS	Median	III,IV	0.182	0.666	<.001	18	view →
SKCM	OS	Median	II,III,IV	0.932	0.803	.002	17	view →
BRCA	OS	Median	All	0.883	0.965	.001	8	view →
BLCA	OS	Median	III,IV	0.212	0.592	.009	6	view →
PRAD	DFS	Median	All	0.796	0.938	.003	6	view →
LUAD	OS	Median	III,IV	0.325	0.534	.022	5	view →
UCEC	DFS	Median	II,III,IV	0.805	0.420	.026	4	view →
COAD	DFS	Median	All	0.900	0.767	.014	4	view →
READ	OS	Median	III,IV	0.328	0.750	.012	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

SPTA1–ACC (DFS)

Open the ACC breakdown →