SPTA1

Across TCGA patient cohorts, SPTA1 protein abundance is significantly associated with the RNA expression of many other genes, with 3,625 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPTA1-associated genes across cancer lineages are HBA1, HBB, and HBA2. Each is linked with SPTA1 in more than 8 cancer types. Because this analysis shows association rather than direction, both SPTA1-to-partner and partner-to-SPTA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPTA1 versus HBA1 in OV, with a Pearson correlation of 0.77.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTA1→partner) and Y-score (partner→SPTA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HBA1 →	+1.494	+0.966	<.001	<.001	3	9
PDAC	HBB →	+2.587	+0.968	<.001	<.001	3	9
PDAC	HBA2 →	+2.347	+1.012	<.001	<.001	3	8
OV	DUSP1 →	+1.668	+0.895	<.001	<.001	3	7
PDAC	PPBP →	+1.231	+0.829	<.001	<.001	3	6
CCRCC	PF4 →	+0.868	+1.184	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,625 associations by consensus.

SPTA1 vs HBA1 — OV

Explore this scatter interactively →