SPTA1

Across TCGA patient cohorts, SPTA1 mutation is significantly associated with the RNA expression of many other genes, with 10,732 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPTA1-associated genes across cancer lineages are PBK, TUBG1, and CCNA2. Each is linked with SPTA1 in more than 8 cancer types. Because this analysis shows association rather than direction, both SPTA1-to-partner and partner-to-SPTA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PBK grouped by SPTA1-low versus SPTA1-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTA1→partner) and Y-score (partner→SPTA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	PBK →	+0.832	+3.230	<.001	.009	2	9
UCEC	TUBG1 →	+0.532	+1.332	<.001	<.001	3	8
LUAD	CCNA2 →	+0.613	+1.082	<.001	<.001	3	8
LUAD	MAD2L1 →	+0.542	+1.986	<.001	<.001	3	8
LUAD	SNRPD1 →	+0.284	+1.874	<.001	<.001	3	8
LUAD	SCNN1B →	-0.774	-1.142	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,732 associations by consensus.

PBK by SPTA1 expression — PRAD

Explore this box plot interactively →