SPTA1

Across TCGA patient cohorts, SPTA1 mutation is significantly associated with the total protein of many other genes, with 107 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPTA1-associated genes across cancer lineages are eIF4E, ASNS, and Cyclin-B1. Each is linked with SPTA1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SPTA1-to-partner and partner-to-SPTA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SPTA1-low versus SPTA1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTA1→partner) and Y-score (partner→SPTA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.150	+2.087	.001	.004	3	6
HNSC	ASNS →	+0.530	+3.000	.007	.033	3	5
LUAD	Cyclin-B1 →	+0.399	+1.710	<.001	<.001	3	5
STAD	Claudin-7 →	+0.897	+2.321	<.001	<.001	3	5
UCEC	4E-BP1 →	+0.197	+1.415	.001	.007	3	5
LUAD	Akt →	-0.171	-1.263	.032	.012	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 107 associations by consensus.

eIF4E by SPTA1 expression — COAD

Explore this box plot interactively →