SPTA1

Across TCGA cell cohorts, SPTA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,522 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPTA1-associated GO terms across cancer lineages are Antigen processing and presentation of peptide antigen via MHC class I, Regulation of CD8-positive, alpha-beta T cell proliferation, and Regulation of miRNA metabolic process. Each is linked with SPTA1 in more than 6 cancer types. Because this analysis shows association rather than direction, both SPTA1-to-partner and partner-to-SPTA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antigen processing and presentation of peptide antigen via MHC class I grouped by SPTA1-low versus SPTA1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTA1→partner) and Y-score (partner→SPTA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Antigen processing and presentation of peptide antigen via MHC class I →	+0.094	+0.098	.004	.009	2	7
BLOOD_Lymphoma	Regulation of CD8-positive, alpha-beta T cell proliferation →	+0.160	+0.742	<.001	.002	3	5
BLOOD_Lymphoma	Regulation of miRNA metabolic process →	+0.032	+0.530	.002	.007	3	5
PANCREAS	Thymic T cell selection →	+0.080	+0.098	.005	.009	3	5
BLOOD_Leukemia	Viral process →	+0.040	+1.823	.001	.007	3	5
BLOOD_Leukemia	Regulation of protein localization to mitochondrion →	+0.060	+1.682	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,522 associations by consensus.

Antigen processing and presentation of peptide antigen via MHC class I by SPTA1 expression — PANCREAS

Explore this box plot interactively →