SPTA1

Across TCGA cell cohorts, SPTA1 mutation is significantly associated with the RNA expression of many other genes, with 823 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPTA1-associated genes across cancer lineages are DIMT1, CCDC163, and GPR63. Each is linked with SPTA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPTA1-to-partner and partner-to-SPTA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DIMT1 grouped by SPTA1-low versus SPTA1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTA1→partner) and Y-score (partner→SPTA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DIMT1 →	+0.496	+1.628	<.001	.002	3	3
LUNG_SCLC	CCDC163 →	+0.551	+3.321	.004	.002	3	3
LARGE_INTESTINE	GPR63 →	+0.720	+2.000	<.001	<.001	3	3
LARGE_INTESTINE	RTP4 →	-0.841	-3.321	.002	.002	3	3
LARGE_INTESTINE	ZNF232 →	+0.590	+2.459	.002	.006	3	3
LARGE_INTESTINE	ZNF397 →	+0.683	+1.628	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 823 associations by consensus.

DIMT1 by SPTA1 expression — LARGE_INTESTINE

Explore this box plot interactively →