SPSB4

Across TCGA patient cohorts, SPSB4 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPSB4-associated genes across cancer lineages are PAI-1, ATM, and MEK1. Each is linked with SPSB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPSB4-to-partner and partner-to-SPSB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAI-1 grouped by SPSB4-low versus SPSB4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPSB4→partner) and Y-score (partner→SPSB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PAI-1 →	+0.399	+3.321	.026	.010	3	1
UCEC	ATM →	-0.529	-3.321	.026	.010	3	1
UCEC	MEK1 →	+0.452	+3.321	.018	.010	1	1
UCEC	Rab25 →	-0.508	-3.321	.003	.010	1	1
UCEC	4E-BP1 →	+0.430	+3.321	.002	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

PAI-1 by SPSB4 expression — UCEC

Explore this box plot interactively →