SPSB4

Across TCGA pan-cancer cohorts, SPSB4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SPSB4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SPSB4 RNA is repressed in tumor relative to normal tissue. In most cancer types SPSB4 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, HNSC, and KICH are the cancer types where SPSB4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPSB4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	All	−0.915	<.001	11	view →
HNSC	All	All	+0.404	.001	9	view →
KICH	Female	II,III,IV	+1.868	<.001	7	view →
KIRC	Male	II,III,IV	−0.750	<.001	7	view →
UCEC	All	II,III,IV	+0.838	.014	6	view →
LIHC	Male	III,IV	−0.555	<.001	5	view →
PAAD	All	All	−0.615	.031	2	view →
BLCA	All	IV	−0.582	.028	2	view →
LUAD	Female	III,IV	−0.282	.029	2	view →
THCA	Female	All	−0.115	<.001	2	view →
PRAD	All	All	−0.109	.007	2	view →
STAD	All	All	−0.251	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SPSB4–KIRP

Open the KIRP breakdown →