SPSB4

Across TCGA cell cohorts, SPSB4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,346 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SPSB4-associated GO terms across cancer lineages are Protein-DNA complex organization, Regulation of transcription initiation by RNA polymerase II, and Regulation of DNA-templated transcription initiation. Each is linked with SPSB4 in more than 11 cancer types. Because this analysis shows association rather than direction, both SPSB4-to-partner and partner-to-SPSB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein-DNA complex organization grouped by SPSB4-low versus SPSB4-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPSB4→partner) and Y-score (partner→SPSB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Protein-DNA complex organization →	+0.069	+1.847	.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Regulation of transcription initiation by RNA polymerase II →	+0.065	+0.204	<.001	.005	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA-templated transcription initiation →	+0.061	+0.203	<.001	.006	3	11
SOFT_TISSUE	Positive regulation of monoatomic ion transport →	-0.109	-2.415	<.001	<.001	3	11
SOFT_TISSUE	RNA splicing, via transesterification reactions →	+0.054	+1.756	<.001	<.001	3	11
LUNG_SCLC	U2-type prespliceosome assembly →	+0.107	+2.010	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,346 associations by consensus.

Protein-DNA complex organization by SPSB4 expression — LUNG_SCLC

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