SPSB4

Across TCGA cell cohorts, SPSB4 mutation is significantly associated with the RNA expression of many other genes, with 1 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPSB4-associated genes across cancer lineages are DEFA1. Each is linked with SPSB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPSB4-to-partner and partner-to-SPSB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA1 grouped by SPSB4-low versus SPSB4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPSB4→partner) and Y-score (partner→SPSB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA1 →	+0.346	+3.920	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 1 strongest of 1 associations by consensus.

DEFA1 by SPSB4 expression — LARGE_INTESTINE

Explore this box plot interactively →