SPSB2

Across TCGA patient cohorts, SPSB2 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,009 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPSB2-associated proteins across cancer lineages are PLEKHA5, USP5, and SCYL2. Each is linked with SPSB2 in more than 4 cancer types. Because this analysis shows association rather than direction, both SPSB2-to-partner and partner-to-SPSB2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPSB2 versus PLEKHA5 in GBM, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPSB2→partner) and Y-score (partner→SPSB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLEKHA5 →	+0.715	+0.405	<.001	.002	3	5
LSCC	USP5 →	+0.224	+0.483	<.001	<.001	3	5
OV	SCYL2 →	+0.249	+0.643	<.001	<.001	3	4
OV	LPCAT3 →	+0.586	+0.817	<.001	<.001	3	4
LSCC	PIR →	+0.797	+0.510	<.001	.001	3	4
HNSC	CD9 →	+0.845	+0.942	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,009 associations by consensus.

SPSB2 vs PLEKHA5 — GBM

Explore this scatter interactively →