SPSB2

Across TCGA pan-cancer cohorts, SPSB2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SPSB2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SPSB2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SPSB2 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRP, BLCA, and HNSC are the cancer types where SPSB2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPSB2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	III,IV	+1.302	<.001	11	view →
BLCA	All	III,IV	+1.053	<.001	10	view →
HNSC	Male	III,IV	+0.991	<.001	10	view →
LIHC	Male	II,III,IV	+1.819	<.001	9	view →
STAD	All	II,III,IV	+0.974	<.001	7	view →
COAD	All	All	+0.409	<.001	6	view →
BRCA	All	All	+0.397	<.001	6	view →
ESCA	All	All	+0.960	.007	4	view →
CHOL	All	All	+2.449	<.001	3	view →
KICH	Female	All	−0.599	.002	3	view →
KIRC	Male	IV	+0.498	.025	1	view →
THCA	Male	III,IV	−0.374	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SPSB2–KIRP

Open the KIRP breakdown →