SPSB2

Across TCGA patient cohorts, SPSB2 mutation is significantly associated with the RNA expression of many other genes, with 372 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPSB2-associated genes across cancer lineages are ASB17, RNU4-88P, and RNU6-1052P. Each is linked with SPSB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPSB2-to-partner and partner-to-SPSB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by SPSB2-low versus SPSB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPSB2→partner) and Y-score (partner→SPSB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASB17 →	+0.169	+2.940	<.001	<.001	3	2
HNSC	RNU4-88P →	+0.332	+7.954	<.001	.008	3	1
HNSC	RNU6-1052P →	+0.288	+7.954	<.001	.008	3	1
UCEC	MMAA →	+0.413	+3.491	.005	.002	3	1
UCEC	GPR180 →	+0.662	+3.346	.001	.005	3	1
UCEC	DGKE →	+0.729	+3.233	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 372 associations by consensus.

ASB17 by SPSB2 expression — UCEC

Explore this box plot interactively →