SPSB2

Across TCGA patient cohorts, SPSB2 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPSB2-associated genes across cancer lineages are Smooth muscle, CMP, and NKT. Each is linked with SPSB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPSB2-to-partner and partner-to-SPSB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smooth muscle grouped by SPSB2-low versus SPSB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPSB2→partner) and Y-score (partner→SPSB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Smooth muscle →	+0.142	+3.016	.023	.019	3	1
UCEC	CMP →	-0.041	-2.311	.007	.036	1	1
UCEC	NKT →	-0.132	-2.321	.013	.036	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Smooth muscle by SPSB2 expression — UCEC

Explore this box plot interactively →