SPRYD7P1

Across TCGA pan-cancer cohorts, SPRYD7P1 RNA is linked to patient survival in 7 of 34 cancer types, making it the most broadly survival-associated SPRYD7P1 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher SPRYD7P1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPRYD7P1 expression acts as an unfavorable survival marker, although some lineages such as OV and HNSC show a favorable association.

BRCA, SKCM, and OV are the cancer types where SPRYD7P1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Tertile	II,III,IV	0.829	0.944	.023	54	view →
SKCM	OS	Tertile	III,IV	0.179	0.801	<.001	48	view →
OV	OS	Tertile	II,III,IV	0.991	0.684	.031	24	view →
UCS	DFS	Tertile	All	0.136	0.523	.034	18	view →
LUAD	OS	Tertile	II,III,IV	0.141	0.677	.002	18	view →
KIRP	OS	Tertile	All	0.280	0.716	.002	9	view →
HNSC	DFS	Tertile	All	0.939	0.633	.049	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SPRYD7P1–BRCA (DFS)

Open the BRCA breakdown →