SPRYD4

Across TCGA patient cohorts, SPRYD4 protein abundance is significantly associated with the RNA expression of many other genes, with 12,832 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPRYD4-associated genes across cancer lineages are BCL2A1, CD300E, and LILRA5. Each is linked with SPRYD4 in more than 4 cancer types. Because this analysis shows association rather than direction, both SPRYD4-to-partner and partner-to-SPRYD4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPRYD4 versus BCL2A1 in BRCA, with a Pearson correlation of -0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRYD4→partner) and Y-score (partner→SPRYD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BCL2A1 →	-1.489	-0.375	<.001	.001	3	5
BRCA	CD300E →	-0.938	-0.370	<.001	<.001	3	5
PDAC	LILRA5 →	-0.695	-0.370	<.001	<.001	3	5
BRCA	DSE →	-0.746	-0.525	<.001	<.001	3	4
BRCA	SOD2 →	-0.750	-0.375	.003	.002	3	4
BRCA	CD86 →	-0.898	-0.508	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,832 associations by consensus.

SPRYD4 vs BCL2A1 — BRCA

Explore this scatter interactively →