SPRY4-AS1

Across TCGA pan-cancer cohorts, SPRY4-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SPRY4-AS1 data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher SPRY4-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPRY4-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

LIHC, ACC, and CESC are the cancer types where SPRY4-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.462	0.606	<.001	86	view →
ACC	DFS	Median	All	0.390	0.769	<.001	76	view →
CESC	DFS	Quartile	All	0.383	0.662	.001	70	view →
BRCA	DFS	Median	III,IV	0.827	0.930	.005	37	view →
LGG	OS	Median	All	0.826	0.963	<.001	36	view →
UVM	OS	Tertile	III,IV	0.417	0.931	.004	32	view →
STAD	OS	Quartile	All	0.390	0.755	.001	30	view →
MESO	OS	Tertile	All	0.331	0.574	.003	27	view →
HNSC	DFS	Quartile	All	0.206	0.491	.001	26	view →
GBM	DFS	Median	All	0.171	0.302	.006	24	view →
SKCM	OS	Quartile	All	0.418	0.260	.002	18	view →
KIRC	DFS	Median	All	0.759	0.511	.001	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SPRY4-AS1–LIHC (DFS)

Open the LIHC breakdown →