SPRY4-AS1

Across TCGA pan-cancer cohorts, SPRY4-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SPRY4-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SPRY4-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SPRY4-AS1 is over-expressed in tumor, although a few such as KIRC and LUSC show the opposite, repressed pattern.

HNSC, COAD, and KIRC are the cancer types where SPRY4-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPRY4-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.242	<.001	12	view →
COAD	Male	All	+0.704	<.001	11	view →
KIRC	Male	II,III,IV	−0.284	<.001	8	view →
LUSC	Female	II,III,IV	−0.644	<.001	6	view →
READ	All	All	+0.513	<.001	4	view →
LUAD	All	All	+0.463	<.001	4	view →
LIHC	Female	All	+0.242	<.001	4	view →
BRCA	Female	II,III,IV	−0.227	<.001	4	view →
KICH	All	All	−0.554	<.001	3	view →
CHOL	All	All	+1.392	<.001	2	view →
PAAD	Female	All	+0.760	.045	2	view →
UCEC	All	All	+0.271	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SPRY4-AS1–HNSC

Open the HNSC breakdown →