SPRY1

Across TCGA patient cohorts, SPRY1 protein abundance is significantly associated with the RNA expression of many other genes, with 5,103 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SPRY1-associated genes across cancer lineages are LINC01091, ASCL5, and DUSP6. Each is linked with SPRY1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPRY1-to-partner and partner-to-SPRY1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPRY1 versus LINC01091 in LUAD, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRY1→partner) and Y-score (partner→SPRY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LINC01091 →	+0.615	+0.731	<.001	<.001	3	4
UCEC	ASCL5 →	-1.044	-0.916	<.001	<.001	3	4
GBM	DUSP6 →	+0.977	+0.807	<.001	<.001	3	4
HNSC	GOSR2 →	-0.375	-0.599	.001	.006	3	3
LSCC	ACAP2 →	-0.867	-0.344	<.001	<.001	3	3
GBM	KIF21B →	-0.998	-0.911	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,103 associations by consensus.

SPRY1 vs LINC01091 — LUAD

Explore this scatter interactively →