SPRY1

Across TCGA patient cohorts, SPRY1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPRY1-associated genes across cancer lineages are A-Raf_pS299, Ku80, and Notch1. Each is linked with SPRY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRY1-to-partner and partner-to-SPRY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by SPRY1-low versus SPRY1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRY1→partner) and Y-score (partner→SPRY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.165	-3.000	.008	.036	3	1
UCEC	Ku80 →	+0.256	+2.183	.039	.035	3	1
UCEC	Notch1 →	+0.155	+3.321	.035	.010	3	1
UCEC	C-Raf →	+0.247	+3.321	.001	.010	3	1
UCEC	N-Ras →	-0.149	-3.308	.017	.010	2	1
UCEC	Rab25 →	-0.574	-3.169	<.001	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

A-Raf_pS299 by SPRY1 expression — UCEC

Explore this box plot interactively →