SPRY1

Across TCGA cell cohorts, SPRY1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,457 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SPRY1-associated GO terms across cancer lineages are Negative regulation of lens fiber cell differentiation, Regulation of lens fiber cell differentiation, and Negative regulation of ERBB signaling pathway. Each is linked with SPRY1 in more than 15 cancer types. Because this analysis shows association rather than direction, both SPRY1-to-partner and partner-to-SPRY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of lens fiber cell differentiation grouped by SPRY1-low versus SPRY1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRY1→partner) and Y-score (partner→SPRY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of lens fiber cell differentiation →	+0.792	+1.552	.006	<.001	3	16
OVARY	Regulation of lens fiber cell differentiation →	+0.474	+2.126	.007	<.001	3	15
LUNG_NSCLC_LUAD	Negative regulation of ERBB signaling pathway →	+0.083	+1.628	<.001	<.001	3	9
PANCREAS	Negative regulation of epidermal growth factor receptor signaling pathway →	+0.062	+1.554	<.001	<.001	3	9
PANCREAS	Negative regulation of Ras protein signal transduction →	+0.091	+1.671	<.001	<.001	3	9
LIVER	Negative regulation of ERK1 and ERK2 cascade →	+0.084	+2.326	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,457 associations by consensus.

Negative regulation of lens fiber cell differentiation by SPRY1 expression — LUNG_SCLC

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