SPRY1

Across TCGA cell cohorts, SPRY1 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPRY1-associated genes across cancer lineages are OBP2A and C6. Each is linked with SPRY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRY1-to-partner and partner-to-SPRY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OBP2A grouped by SPRY1-low versus SPRY1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRY1→partner) and Y-score (partner→SPRY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OBP2A →	+0.073	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	C6 →	+0.194	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

OBP2A by SPRY1 expression — BLOOD_Leukemia

Explore this box plot interactively →