SPRR5

Across TCGA cell cohorts, SPRR5 RNA expression is significantly associated with the go_rna of many other GO terms, with 181 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible SPRR5-associated GO terms across cancer lineages are Cellular response to peptidoglycan, Inner ear receptor cell development, and Intestinal hexose absorption. Each is linked with SPRR5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPRR5-to-partner and partner-to-SPRR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to peptidoglycan grouped by SPRR5-low versus SPRR5-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR5→partner) and Y-score (partner→SPRR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cellular response to peptidoglycan →	-0.236	-1.625	<.001	.006	3	3
UPPER_AERODIGESTIVE_TRACT	Inner ear receptor cell development →	-0.099	-1.367	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	Intestinal hexose absorption →	-0.112	-0.875	.008	.008	3	2
UPPER_AERODIGESTIVE_TRACT	Positive regulation of G2/M transition of mitotic cell cycle →	-0.097	-1.229	.001	.008	3	2
UPPER_AERODIGESTIVE_TRACT	Meiotic nuclear division →	-0.047	-0.910	.002	.006	3	2
UPPER_AERODIGESTIVE_TRACT	Extracellular vesicle biogenesis →	+0.101	+0.986	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 181 associations by consensus.

Cellular response to peptidoglycan by SPRR5 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →