Across TCGA patient cohorts, SPRR4 protein abundance is significantly associated with the RNA expression of many other genes, with 4,922 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SPRR4-associated genes across cancer lineages are SLC5A1, FERMT1, and CHRDL1. Each is linked with SPRR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRR4-to-partner and partner-to-SPRR4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR4→partner) and Y-score (partner→SPRR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLC5A1 →	+0.884	+1.631	.003	.001	3	2
LSCC	FERMT1 →	+1.135	+2.097	<.001	<.001	3	2
HNSC	CHRDL1 →	-1.404	-2.026	.002	<.001	3	2
LSCC	HAS3 →	+1.585	+2.127	.003	.002	3	2
LSCC	TGM5 →	+1.311	+2.639	<.001	<.001	3	2
LSCC	CNFN →	+2.228	+2.266	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,922 associations by consensus.

Exploration

SPRR4 survival (RNA) · tumor vs normal (RNA) · all SPRR4 data types